Medical Definition of Fourth Disease (Dukes' Disease) (2024)

Fourth disease is a disorder characterized by a rash due to a toxin produced by Staphylococcus aureus (Staph aureus bacteria).

Measles and scarlet fever were differentiated from one another in the 17th century. Rubella was accepted as the third distinct pediatric exanthem (rash) in 1881. What were thought to be two distinct forms of rubella were then described and it was proposed that one of these forms of rubella was a separate entity that was called fourth disease. For many years, fourth disease was considered a non-entity, perhaps a mild form of scarlet fever, but certainly not a distinct disease. Now it is clear that fourth disease is caused by exotoxin-producing Staph aureus.

Fourth disease is also known as Filatov-Dukes disease or Dukes' disease.

References

Jameson, J. Larry, et al. Harrison's Principles of Internal Medicine, 20th Ed. New York: McGraw-Hill Education, 2018.

Medical Definition of Fourth Disease (Dukes' Disease) (2024)

FAQs

Medical Definition of Fourth Disease (Dukes' Disease)? ›

Fourth disease is a disorder characterized by a rash due to a toxin produced by Staphylococcus aureus (Staph aureus bacteria). Measles and scarlet fever were differentiated from one another in the 17th century. Rubella was accepted as the third distinct pediatric exanthem

exanthem
An exanthem is a widespread rash occurring on the outside of the body and usually occurring in children. It is usually caused by a virus, but an exanthem can be caused by bacteria, toxins, drugs, other microorganisms, or as the result from autoimmune disease.
https://en.wikipedia.org › wiki › Exanthem
(rash) in 1881.

What is Duke's disease? ›

Dukes' disease, named after Clement Dukes, also known as fourth disease or Filatov-Dukes' disease (after Nil Filatov), is an exanthem. It is distinguished from measles or forms of rubella, though it was considered as a form of viral rash.

What is the causative agent of Duke's disease? ›

Filatow-Dukes' disease. Epidermolytic toxin-producing staphylococci as the etiologic agent of the fourth childhood exanthem.

What are the six diseases? ›

The name "sixth disease" comes from its place on the standard list of rash-causing childhood diseases, which also includes measles (first), scarlet fever (second), rubella (third), Dukes' disease (fourth, but is no longer widely accepted as distinct from scarlet fever), and erythema infectiosum (fifth).

What is the first disease of childhood? ›

First Disease: measles virus (Rubeloa) Third Disease: rubella virus (German measles) Fifth Disease: parvovirus B19 (Erythema infectiosum) Sixth Disease: Human Herpes Viruse 6 (roseola infantum)

What is the name of the fourth disease? ›

For many years, fourth disease was considered a non-entity, perhaps a mild form of scarlet fever, but certainly not a distinct disease. Now it is clear that fourth disease is caused by exotoxin-producing Staph aureus. Fourth disease is also known as Filatov-Dukes disease or Dukes' disease.

What is the 5th 6th disease? ›

Fifth (erythema infectiosum) and sixth (roseola infantum) diseases are common rash illnesses of childhood that have long been recognized in clinical medicine. The discovery of the viruses that cause these illnesses has revealed relationships with other syndromes.

What is the fifth day disease? ›

Fifth disease is a mild illness caused by a virus called parvovirus B19. It is rarely serious. Its most obvious symptom is the bright red rash or “slapped cheek” look of the face. The disease occurs most often during the late winter and early spring in children between the ages of 4 and 10.

What viruses cause itching? ›

Viruses that commonly cause exanthem rash include:
  • Chickenpox (varicella-zoster virus).
  • COVID-19 (coronavirus).
  • Fifth disease (parvovirus B19).
  • Hand, foot and mouth disease(coxsackievirus A16).
  • Measles (morbillivirus).
  • Roseola (human herpesvirus 6).
  • Rubella (rubella virus).

What is the sixth disease rash? ›

Roseola (roe-zee-OH-lah) is a viral illness that most commonly affects kids between 6 months and 2 years old. It's also known as sixth disease, exanthem subitum, and roseola infantum. It is usually marked by several days of high fever, followed by a distinctive rash just as the fever breaks.

What old diseases are coming back? ›

Worrisome Diseases That Are Still Around
  • Plague. 1/13. It's hard to believe, but the Black Death isn't just one for the history books or far-flung places. ...
  • Tuberculosis (TB) 2/13. ...
  • Syphilis and Chlamydia. 3/13. ...
  • Scarlet Fever. 4/13. ...
  • Measles. 5/13. ...
  • Mumps. 6/13. ...
  • Whooping Cough. 7/13. ...
  • Legionnaires' Disease. 8/13.
Aug 28, 2023

What are the 4 major diseases? ›

There are four main types of disease: infectious diseases, deficiency diseases, hereditary diseases (including both genetic and non-genetic hereditary diseases), and physiological diseases.

What was the first disease known to man? ›

The oldest known diseases include cholera, typhoid, leprosy, smallpox, rabies, malaria, pneumonia, tuberculosis, trachoma and Rocky Mountain spotted fever, each documented through various means including bone lesions, DNA testing and ancient texts.

What is the deadliest childhood disease? ›

Pneumonia. Pneumonia is the leading infectious cause of death among children under 5, killing approximately 700,000 children a year. In many parts of the world, a child dies from pneumonia every minute – even though the disease is entirely preventable and can be easily managed with antibiotics.

What is the most chronic childhood disease? ›

Dental cavities (also known as caries or decay) is the most common chronic disease in children: it is about 5 times more common than asthma and 7 times more common than hay fever1.

What is the only disease that has been eradicated? ›

In 1980 WHO declared smallpox eradicated – the only infectious disease to achieve this distinction. This remains among the most notable and profound public health successes in history.

What are the symptoms of parvo in humans? ›

History. Common symptoms of parvovirus B19 (B19V) infection include a mild nonspecific prodromal illness that may consist of fever (15-30% of patients), malaise, headache, myalgia, nausea, and rhinorrhea; typically beginning 5-7 days after initial infection.

Why is it called the fifth disease? ›

Fifth disease is a mild rash illness caused by parvovirus B19. This disease, also called erythema infectiosum, got its name because it was fifth in a list of historical classifications of common skin rash illnesses in children. It is more common in children than adults.

What are the symptoms of fifth disease in adults? ›

Adults usually don't get a rash, but they do tend to get more serious flu-like symptoms, including:
  • Headache.
  • Sore throat.
  • Muscle pain.
  • Joint pain, particularly in the hands, wrists, knees, and ankles.
  • Belly pain.
  • Fever.
Sep 28, 2023

What does a slap cheek look like? ›

Slapped cheek disease is characterised by bright red cheeks, a cold-like illness and, sometimes, an itchy rash on the torso and limbs. It commonly affects primary school children and is not dangerous for most people.

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